![]() ![]() (30,31) The low-biocompatibility and biotoxicity of these materials not only result in inconvenience in practical operation but also lead to subsequent pollution after being discharged into the environment. However, tedious synthesis, purification, and/or complicated modification are generally required for the preparation of these fluorescent probes (26−29) in particular, most fluorescent materials are not out of the limit which originates from their low-biocompatibility and even biotoxicity. Undoubtedly, distinct advance for biochemical sensing have been made by these developed fluorescent methods. (25) These fluorescent materials have provided tools for constructing probes in analytical chemistry. In the past years, with the development of molecular engineering and nanotechnology, multifarious fluorescent materials have been designed and synthesized, such as inorganic fluorescent metal nanoparticles (24) and organic fluorophores. (23) Thus, the analysis and monitoring of copper ion in environment and food samples have become increasingly significant.įluorescent analysis strategy has attracted great interest by virtue of the high sensitivity, simple operation, and fast detection speed of fluorescence technique. Environmental Protection Agency (EPA) and the World Health Organization (WHO). (20−22) The safety limit of copper ion in drinking water has been, respectively, set at 1.3 mg/L (ac. (11−13) Some associations have been discovered between the risk and a few of serious diseases, including amyotrophic lateral sclerosis, (14,15) Menkes syndrome, (16,17) Alzheimer’s disease, (18,19) and Wilson’s disease. (8−10) Over-ingestion of copper ion (Cu 2+) can result in severe damages in gastrointestinal, kidney, and liver by facilitating the generation of reactive oxygen species that can disorder the cellular metabolism balance. Especially in drinking water, its toxicity has been deemed to be second only to mercury ion. (5−7) However, on the opposite side, copper is becoming one of the major heavy-metal environmental pollutants, with the increasing of industrial pollution and mineral corrosion. In living organisms, copper at low concentration levels plays an important role as a micronutrient, through cofactor-dependent activation of many protein enzymes, (1−4) and is the third transition metal essential to human health following zinc and iron. ![]() It had a rapid response to the target ion via a coordination-mediated PET effect, the signal change reached the maximum within 10 s cell proliferation experiments verified that the screened peptide had excellent biocompatibility, implying that it had great environment-friendliness and convenience for practical application in Cu 2+ detection high selectivity and a wide linear detection range from 10 to 1500 nM were achieved, with a lowest detectable concentration of 10 nM, which are superior to conventional optical strategies through analysis of real water samples, good recoveries and consistencies with classical inductively coupled plasma mass spectrometry indicated that this strategy had promising potential for practical application, especially significant for Cu 2+ detection in drinking water and in addition, Cu 2+ antidotes identification was successfully carried out, implying useful contribution to medical therapy and sewage treatment. By virtue of rich coordination sites (amidogen and carboxyl) and fluorescence property of aromatic amino acids that which are also essential for living organism, monomers and combinations of them are designed to interact with Cu 2+, attractively, the short peptide of tryptophane–phenylalanine (Trp–Phe) held stronger fluorescence emission and displayed much more significant response to Cu 2+ than other molecules thus, Trp–Phe was screened as a new fluorescent sensor for Cu 2+ detection. Here, we made effort to develop a new sensor with above advantages for Cu 2+ detection. However, the Cu 2+ detection strategy with high-efficient and biocompatibility maintains importance. ![]() Copper, one of the most important metal elements, has been a new favorite in research areas. ![]()
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